The Metabolic Road to Diastolic Heart Failure: Diastolic Heart Failure Study (MEDIA-DHF)

Central Hospital, Nancy, France

Status: Completed

Conditions: Diastolic Heart Failure

Treatments: Other: Blood sampling for biomarker assessment

Study type: Interventional

Funder types: Other

Identifiers

NCT02446327

2012-A00097-36

Details and patient eligibility

About

The main objective is to replicate the validation of omics biomarkers of left ventricular diastolic dysfunction in patients with metabolic syndrome.

The aim was to recruit overall 750 patients in Europe (100 for France). Currently, 625 patients were enrolled in Europe and 47 in France.

Enrollment: 47 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients 18 years of age or older
• Signs or symptoms of HF
• Able and willing to provide freely given written informed consent including analysis of genomics

Exclusion criteria

• Patients with acute myocardial infarction
• Recent trauma or surgery (< 3 months)
• Hemodynamically significant valvular disease
• Serious cerebrovascular disease or stroke in the last 3 months
• Chronic dialysis
• Chronic liver disease
• Chronic infectious (bacterial or viral) disease
• Any malignant concomitant diseases or a malignant disease in the last 5 years
• Systemic inflammatory diseases, such as autoimmune diseases, connective tissue diseases or collagenoses
• Pregnant women

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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47 participants in 1 patient group

Diastolic heart failure cohort

Other group

Description:

This is a prospective cohort of patients with diastolic heart failure. Blood sampling for biomarker assessment

Treatment:

Other: Blood sampling for biomarker assessment