The Microcirculation in Acute Myocardial Infarction (Micro-AMI)

University of Bristol

Status: Completed

Conditions: STEMI

Treatments: Other: Cardiac magnetic resonance; Procedure: Index of microvascular resistance; Other: Blood markers

Study type: Observational

Funder types: Other

Identifiers

NCT01552564

1625

Details and patient eligibility

About

This study investigates the association between the microvascular resistance at the time of primary percutaneous intervention, with microvascular obstruction on CMR and blood markers of myocardial damage.

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• >18 years old
• Cardiac symptoms of > 20 mins chest pain or equivalent.
• ECG criteria consistent with STEMI (STEMI)
• Proceeding with percutaneous angioplasty
• Assent/ consent to the study

Exclusion criteria

• Known allergy to adenosine or gadolinium
• Chronic atrial fibrillation
• Renal impairment with eGFR <30
• Contraindication to angiography
• Contraindication to CMR (implanted pacemaker/ defibrillator, ferromagnetic metal implant/ injury, claustrophobia, obesity/ too large for CMR scanner)
• Cardiogenic shock
• Patients with special communication needs or altered consciousness.
• Patients who do not give assent/consent to the study

Trial design

50 participants in 1 patient group

STEMI patients

Description:

Consecutive patients presenting through the PPCI service

Treatment:

Procedure: Index of microvascular resistance

Other: Cardiac magnetic resonance

Other: Blood markers