The Molecular Pathogenesis of Late-onset Fuchs' Endothelial Corneal Dystrophy

Universitaire Ziekenhuizen KU Leuven

Status: Completed

Conditions: Fuchs' Endothelial Dystrophy

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT01795001

S55133

Details and patient eligibility

About

The purpose of this study is to gain further insights into the molecular pathogenesis of Fuchs' endothelial corneal dystrophy (FECD), to identify targets for potential specific drug therapy.

Enrollment: 460 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• FECD
• normal corneas (including enucleations for uveal melanoma)
• non-FECD oedematous corneas

Exclusion criteria

• prior irradiation therapy for uveal melanoma
• corneal extension of uveal melanoma

Trial design

460 participants in 3 patient groups

late-onset FECD

Description:

tissue samples from patients with late-onset Fuchs' endothelial corneal dystrophy (FECD)

Treatment:

Other: No intervention

normal control

Description:

tissue samples from patients with normal corneas

Treatment:

Other: No intervention

non-FECD edematous control

Description:

tissue samples from patients with corneal edema but without FECD

Treatment:

Other: No intervention