The Molecular Pathogenesis of Late-onset Fuchs' Endothelial Corneal Dystrophy

U

Universitaire Ziekenhuizen KU Leuven

Status

Completed

Conditions

Fuchs' Endothelial Dystrophy

Treatments

Other: No intervention

Study type

Observational

Funder types

Other

Identifiers

NCT01795001
S55133

Details and patient eligibility

About

The purpose of this study is to gain further insights into the molecular pathogenesis of Fuchs' endothelial corneal dystrophy (FECD), to identify targets for potential specific drug therapy.

Enrollment

460 patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

  • FECD
  • normal corneas (including enucleations for uveal melanoma)
  • non-FECD oedematous corneas

Exclusion criteria

  • prior irradiation therapy for uveal melanoma
  • corneal extension of uveal melanoma

Trial design

460 participants in 3 patient groups

late-onset FECD
Description:
tissue samples from patients with late-onset Fuchs' endothelial corneal dystrophy (FECD)
Treatment:
Other: No intervention
normal control
Description:
tissue samples from patients with normal corneas
Treatment:
Other: No intervention
non-FECD edematous control
Description:
tissue samples from patients with corneal edema but without FECD
Treatment:
Other: No intervention

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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