The "Motoric Cognitive Risk" Syndrome in the Quebec Population

Jewish General Hospital

Status

Active, not recruiting

Conditions

Cognition Disorders in Old Age

Dementia

Treatments

Other: Summarize of participants' characteristics using means and standard deviations or frequencies and percentages

Study type

Observational

Funder types

Other

Identifiers

NCT03633253

CODIM-FLP-16 288

Details and patient eligibility

About

The overall objective of the proposal is to examine the epidemiology of the newly reported "motoric cognitive risk" (MCR) syndrome, which is a pre-dementia syndrome combining subjective cognitive complaint (i.e.; memory complaint) with objective slow gait speed, in the Quebec elderly population.

Cognition and locomotion are two human abilities controlled by the brain. Their decline is highly prevalent with physiological and pathological aging, and is greater than the simple sum of their respective prevalence, suggesting a complex age-related interplay between cognition and locomotion. Both declines in cognition and locomotion are associated, furthermore the temporal nature of their association has been unclear for a long time. Recently, a systematic review and meta-analysis has provided evidence that poor gait performance predicts dementia and, in particular, has demonstrated that MCR syndrome is a pre-dementia syndrome, suggesting that low gait performance is the first symptom of dementia. The uniqueness of MCR syndrome is that it does not rely on a complex evaluation or laboratory investigations. Indeed, this syndrome combined subjective cognitive complaint and objective slow gait speed, and is easy to apply in population-based settings.

Prevalence and incidence of MCR syndrome, as well as its association with incidence of cognitive decline and impairment, have never been reported in Canada. Nutrition as a determinant of successful aging: The Quebec longitudinal Study (the NuAge study) is a Quebec population-based observational cohort study performed in healthy older community-dwellers adults which provides a unique opportunity to: 1) obtain reliable estimates of MCR syndrome prevalence and incidence, 2) determine the distribution of clinical characteristics associated with MCR syndrome, 3) examine the association of MCR syndrome with cognitive decline and incidence of cognitive impairment in the Quebec elderly population.

Enrollment

1,741 estimated patients

Sex

All

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Individuals eligible for this study will be participants of the NuAge study

Exclusion criteria

Individuals not eligible for the NuAge study, No information about cognitive complaint, No measure of walking speed, No follow-up completed