The Muscle Protein Synthetic Response of Algal and Fungal Protein (SCAM)

University of Exeter

Status: Completed

Conditions: Muscle Metabolism

Treatments: Dietary Supplement: Protein ingestion

Study type: Interventional

Funder types: Other

Identifiers

NCT05016557

200506/B/01

Details and patient eligibility

About

Dietary protein intake is vital for the maintenance of skeletal muscle mass and health. The production of animal-based proteins sources is associated with growing environmental and ethical challenges. As such, sustainable alternatives are needed. Algae are sustainably produced high-protein sources and it is predicted that algae will become one of the most consumed proteins in the next decades. However, the effects of algae on the stimulation of muscle mass growth are unknown. Therefore, we aim to assess the rate of digestion and absorption, and the effects on muscle growth of two types of algae (spirulina and chlorella) when compared to a sustainable non-animal derived fungal reference protein (mycoprotein), a source known to elicit a robust anabolic response.

Enrollment: 36 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI between 18.5 and 30
• Recreationally active (<3 times per week structured resistance exercise training)

Exclusion criteria

• Any metabolic impairment
• Any cardiovascular impairment
• High blood pressure (>140/90 mmHg)
• A personal history of epilepsy, seizures or schizophrenia
• Smoking
• Chronic (>1 month) use of over the counter pharmaceuticals
• Chronic (>2 months) use of amino acid or protein supplements
• Allergic to Quorn/mycoprotein or algae products

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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36 participants in 3 patient groups

Mycoprotein

Experimental group

Description:

Bolus ingestion of mycoprotein providing 25g protein

Treatment:

Dietary Supplement: Protein ingestion

Spirulina

Experimental group

Description:

Bolus ingestion of spirulina providing 25g protein

Treatment:

Dietary Supplement: Protein ingestion

Chlorella

Experimental group

Description:

Bolus ingestion of chlorella providing 25g protein

Treatment:

Dietary Supplement: Protein ingestion