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The Need for FibEr Addition in SympTomatic Heart Failure (FEAST-HF)

U

University of Alberta

Status

Completed

Conditions

Heart Failure

Treatments

Dietary Supplement: Acacia Gum

Study type

Interventional

Funder types

Other

Identifiers

NCT03409926
Pro00078692

Details and patient eligibility

About

FEAST-HF is a single-centre clinical trial in ambulatory patients with chronic HF to evaluate whether dietary supplementation with acacia gum reduces HF-related biomarkers NT-proBNP and ST2 and how the gut microbiome responds to dietary supplementation with acacia gum. The hypotheses of this study are 1) that changes in the gut microbiome will be correlated with a reduction in NT-proBNP and ST2 in patients with HF after treatment with acacia gum, and 2) gut microbiome configurations (composition, diversity), stability and function (gene content) will be significantly altered in patients with HF in response to acacia gum.

Enrollment

51 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • 18 years of age or older
  • Willing and able to provide informed consent
  • Patients with established Heart Failure (as per their treating physician) including those with both reduced and preserved ejection fraction

Exclusion criteria

  • Patients requiring a special diet that would prohibit the intervention (e.g. celiac disease, irritable bowel disease)
  • Patients who do not control their own meals (e.g. meals-on-wheels, long-term care)
  • Patients with conditions that would interfere with the analysis of the microbiome (e.g. chronic diarrhea, recent antibiotics within the past month)

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

51 participants in 3 patient groups

Microcrystalline Cellulose (MCC) 10 grams/day
Active Comparator group
Description:
non-fermentable active control
Treatment:
Dietary Supplement: Acacia Gum
Acacia Gum 5 grams/day
Experimental group
Description:
fermentable dietary fiber
Treatment:
Dietary Supplement: Acacia Gum
Acacia Gum 10 grams/day
Experimental group
Description:
fermentable dietary fiber
Treatment:
Dietary Supplement: Acacia Gum

Trial contacts and locations

3

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Data sourced from clinicaltrials.gov

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