The Need of Revisiting to an Outpatient Clinic After the Prescription of Vonoprazan or Esomeprazole

Showa Inan General Hospital

Status: Completed

Conditions: Gastroesophageal Reflux

Treatments: Drug: Esomeprazole; Drug: Vonoprazan

Study type: Interventional

Funder types: Other

Identifiers

NCT04720781

Revisiting

Details and patient eligibility

About

After vonoprazan (20mg/day) or esomeprazole (20mg/day) for 4weeks is prescribed for patients with erosive esophagitis diagnosed by esophagogastroduodenoscopy, the number of patients who will visit our outpatient clinic again due to some reasons without any appointments is compared with vonoprazan group and esomeprazole.

Full description

1. Patients who have erosive esophagitis diagnosed by esophagogastroduodenoscopy is enrolled.
2. Vonoprazan (20mg/day) or esomeprazole (20mg/day) is prescribed for 4weeks the patients randomly without next appointments.
3. Some patients may visit our outpatient clinic again due to some reasons without any appointments.
4. The number of the patients who revisit our outpatient clinic again is compared with vonoprazan group and esomeprazole.

Enrollment: 300 patients

Sex: All

Ages: 19 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• outpatients belonging to American Society of Anesthesiologists class I or II
• patients have erosive esophagitis diagnosed by esophagogastroduodenoscopy shortly before the prescription

Exclusion criteria

• other acid blockers are taken

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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300 participants in 2 patient groups, including a placebo group

Vonoprazan

Active Comparator group

Description:

Vonoprazan (20mg/day) is prescribed for patients with erosive esophagitis

Treatment:

Drug: Vonoprazan

Esomeprazole

Placebo Comparator group

Description:

Esomeprazole (20mg/day) is prescribed for patients with erosive esophagitis

Treatment:

Drug: Esomeprazole