The Neural Correlates of Cannabis Use (Multimodal)

Yale University

Status: Completed

Conditions: Cannabis Dependence; Healthy

Treatments: Drug: [11-C]OMAR

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT03104257

1308012514

1R01DA040698-01A1 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and after four weeks confirmed abstinence. This research will also examine associations between CB1R availability, neural oscillations and cognitive function.

Full description

The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and after four weeks confirmed outpatient abstinence (confirmed by tracking creatinine adjusted urine THC-COOH levels). This research will also examine associations between CB1R availability, neural oscillations and cognitive function using [11-C]OMAR PET imaging and electroencephalography.

Enrollment: 162 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: Cannabis Dependent Subjects

• Current cannabis consumption
• Willing to abstain from cannabis use for four weeks

Inclusion Criteria for Healthy Controls

• No current cannabis consumption

Exclusion Criteria:

• MRI metal exclusions and claustrophobia
• Education completed is less than 12 years

Trial design

162 participants in 2 patient groups

Cannabis Dependent Subjects

Description:

Subjects who are frequent cannabis users

Treatment:

Drug: [11-C]OMAR

Healthy Controls

Description:

Subjects with no current cannabis use

Treatment:

Drug: [11-C]OMAR