The Neural Correlates of Food Choice Decision-making in Obesity and Weight Loss (CHOICES)

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Lifespan

Status

Unknown

Conditions

Weight Loss
Weight Control
Obesity

Treatments

Behavioral: CHOICES - obese

Study type

Interventional

Funder types

Other
NIH

Identifiers

NCT01218503
K01DK090445 (U.S. NIH Grant/Contract)
BRAIN-T32

Details and patient eligibility

About

This study is designed to determine whether obese, normal weight, and successful weight loss maintainers differ in their food choice decision-making and/or executive function, and whether participation in a behavioral weight loss program leads to neural and/or behavioral changes. The investigators will examine behavioral performance on several tasks involving decision-making and self-control in conjunction with brain imaging data acquired during a food-choice decision-making task. Participants enrolled in the behavioral weight loss program will also be assessed following the treatment.

Enrollment

90 estimated patients

Sex

Female

Ages

35 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • women, ages 35-55, who are either currently obese (BMI = 30-40 kg/m2), always normal weight (lifetime BMI < 25, NW) or successful weight loss maintainers who have lost 10% of their body weight and maintained that loss for at least 1 year (lifetime maximum BMI = 30-40 kg/m2)

Exclusion criteria

  • weight loss medications, binge eating, standard MRI contraindications (e.g., metal implants, claustrophobia, pregnancy), left-handedness, food allergies, neurological or psychiatric conditions, including but not limited to schizophrenia, bipolar disorder, epilepsy, stroke and traumatic brain injury with loss of consciousness, and, among obese participants, inability to participate at two time points and lack of interest in participating in a behavioral weight loss trial
  • serious current physical disease (e.g., heart disease and cancer) for which physician supervision of diet and exercise prescription is needed, physical problems that limit the ability to exercise, participation in a weight loss program in the last 2 months and intention to become pregnant in the next 6 months

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

90 participants in 1 patient group

CHOICES - obese
Experimental group
Description:
behavioral weight loss treatment - overweight/obese females
Treatment:
Behavioral: CHOICES - obese

Trial contacts and locations

1

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Central trial contact

Kathryn E Demos, PhD

Data sourced from clinicaltrials.gov

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