The Neural Substrates for Working Memory Training (WMT)

China Rehabilitation Research Center

Status and phase: Unknown; Phase 3; Phase 2

Conditions: Rehabilitation; Working Memory

Treatments: Behavioral: Working memory training

Study type: Interventional

Funder types: Other

Identifiers

NCT03012269

NSFC-81272165

Details and patient eligibility

About

This study aims to conduct a contrast study on the characteristics of functional and structural connectivity of neural networks of working memory in patients with acquired brain injury versus normal controls, using resting-state functional connectivity magnetic resonance imaging, task-specific functional magnetic resonance imaging and diffusion tensor imaging, combined with cognitive behavioral examinations. Another purpose is to reveal the characteristics of dynamic change of neural networks of working memory pre- and post-intervention in patients with working memory dysfunction.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Right handedness
• Diagnosis of traumatic brain injury or stroke
• Course of disease within one year
• The score of MoCA test > 24
• Able to understand instructions

Exclusion criteria

• Aphasia, unilateral spatial neglect, agnosia, apraxia
• Hearing impairment or visual impairment
• History of taking psychiatric drugs

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

40 participants in 2 patient groups

Working Memory Training

Experimental group

Description:

The subjects of experimental group received a series of working memory training, 30 min for 5 days per week during 6 weeks.

Treatment:

Behavioral: Working memory training

Non-Working Memory Training

No Intervention group

Description:

The subjects of control group performed traditional cognitive rehabilitation without working memory training, 30 min for 5 days per week during 6 weeks.