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The Neurological Pupil Index (NPi) on Intensive Care Unit (ICU) Trial (NPI-ON-ICU)

Charité University Medicine Berlin logo

Charité University Medicine Berlin

Status

Completed

Conditions

Hypoxic Encephalopathy

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

The trial will evaluate the use of the "Neurological Pupil index" NPi, measured with the digital pupillometer (NeurOptics) compared to clinical examination for better reliability. The investigators hypothesize that digital evaluation will offer a higher sensitivity/ specificity compared to clinical examination.

Full description

Absent pupillary reaction after cardiac arrest might indicate a severe hypoxic encephalopathy. Because the examination of the pupillary reaction is easy it is part of the clinical routine but due to the different medication and the dynamic process of reperfusion injury to the brain a clinical evaluation might be not precise enough. The NPi has been shown to be superior to clinical evaluation in different settings but without regard towards cardiac arrest survivors. The Pupillometer is a hand-held, cordless, and simple to use device which removes subjectivity in the measurement of pupil size and the pupillary light reflex.

Enrollment

100 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • all survivors after cardiac arrest

Exclusion criteria

  • underlying disease limiting the pupillary reflex

Trial design

100 participants in 1 patient group

Neurological Pupil index
Description:
The NPi will be measured during treatment

Trial contacts and locations

2

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Data sourced from clinicaltrials.gov

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