The Neuromarker S-100B in Patients With Different Types of Intracranial Injury

Medical University of Vienna

Status: Completed

Conditions: Traumatic Brain Injury; Trauma

Study type: Observational

Funder types: Other

Identifiers

NCT01619293

Wolf-5

Details and patient eligibility

About

Abstract:

The most widely studied neuro-markers in traumatic brain injury (TBI) are S100B and neurone specific enolase (NSE). S-100B is localized in astroglia. This marker is used to predict neuronal damage caused by traumatic brain injury. The investigators conduct a study to derive and validate the measurement of S-100B in serum of patients with different types traumatic brain injuries.

Full description

The neuromarker S-100B is a well established tool for decision making in patients traumatic brain injury (TBI)in Europe. In many hospitals S-100B is used routinely as a part of a set of high- and medium risk factors aiding the decision to perform a cranial computed tomography (CCT) in patients with minor head injury (MHI). In patients with severe head injury Raabe et al. found a significant correlation between the S-100B levels and unfavourable outcome in patients with severe brain injury with serum levels higher than 0.50 μg/l measured 24h after injury. The average level of the neuromarker, compared with other studies. The study of Biberthaler et al. showed highest levels in patients with epidural hematomas, followed by subdural, subarachnoidal and intracerebral hematomas. On the contrary the average S-100B levels of patients with epidural hematomas featured in a study by Unden et al. published in 2005 displayed normal levels (<0.2 μg/L). They concluded that S-100B was unreliable as a marker for epidural hematomas.

Aim of the study Validation of S-100B in patients with intracerebral, epidural, subdural, and subarachnoidal hematoma, brain edema and concussion (Group 1-6), to find evidence which kind of injury leads to which level of elevation of the neuromarker measured in peripheral blood.

Enrollment: 1,800 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• all patients with traumatic brain injury

Exclusion criteria

• patients without traumatic brain injury

Trial design

1,800 participants in 6 patient groups

Epidural H.

Description:

patients with hematoma epidurale

Subdural H.

Description:

patients with hematoma subdurale

Subarachnoidal H.

Description:

patients with hematoma subarachnoidale

Intracerebral H.

Description:

patients with hematoma intracerebrale

E. cerebri

Description:

patients with edema cerebri

Concussion

Description:

patients with concussion