The Neuroprotection Effect of Dexmedetomidine

Ajou University School of Medicine

Status: Unknown

Conditions: Dexmedetomidine

Treatments: Drug: Dexmedetomidine; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT03927963

AJIRB-MED-OBS-18-478

Details and patient eligibility

About

The brain protection effect of dexmedetomidine has been approved in several studies.

Basically, the anti-inflammatory effects and reducing catecholamines are thought to be a main role of the protection effect. In many studies reported the advantage of dexmedetomidine as a substitution of other sedative drugs for anesthesia.

The anesthesia of intra-cranial aneurysmal clipping operation commonly use intravenous anesthetic agents combined with inhalation anesthesia for neuroprotection, and mostly propofol is used.

The aim of this study is to examine the effects of dexmedetomidine on serum inflammatory markers and research the hemodynamic stability of dexmedetomidine compared to propofol in aneurysmal clipping operation.

Enrollment: 70 estimated patients

Sex: All

Ages: 19 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA class I,II patient needs operation of intracranial aneurysmal clipping without SAH

Exclusion criteria

• Any history of neurologic disease, dementia
• Allergic history of propofol or dexmedetomidine

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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70 participants in 2 patient groups, including a placebo group

propofol

Placebo Comparator group

Treatment:

Drug: Propofol

dexmedetomidine

Active Comparator group

Treatment:

Drug: Dexmedetomidine