The Neuroprotection of Sevoflurane Preconditioning on Intracranial Aneurysm Surgery

Air Force Military Medical University of People's Liberation Army

Status: Unknown

Conditions: Brain Ischemia

Treatments: Procedure: Sev-I group; Procedure: Sevo continuous inhalation

Study type: Interventional

Funder types: Other

Identifiers

NCT01204268

APC-BRAIN-2009

Details and patient eligibility

About

The current study is designed to clarify the neuroprotective effect of sevoflurane preconditioning on the patients underwent intracranial aneurysm surgery.

Full description

The current study is designed to clarify the neuroprotective effect of sevoflurane preconditioning on the patients underwent intracranial aneurysm surgery. The patients with cerebral aneurysm will be recruited in current study. The sevoflurane preconditioning will be performed before the surgical procedure. The neurological injury biomarkers, such as S-100b and NSE will be detected. The neurological function and recovery will be assessed after the surgery.

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient under intracranial aneurysm surgery.

Exclusion criteria

• Patients who refused to participate or who had a history of chemotherapy/convulsions two weeks prior to admission, stroke/cardiopulmonary resuscitation/head trauma three months prior to admission, Alzheimer's disease, amyotrophic lateral sclerosis, and prior melanoma were excluded.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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80 participants in 3 patient groups

Propofol group

No Intervention group

Description:

Patients will receive the total intravenous anesthesia with propofol infusion during the surgery.

Sevo-C group

Active Comparator group

Description:

Patients will receive the anesthesia with continuous inhalation of sevoflurane.

Treatment:

Procedure: Sevo continuous inhalation

Sevo-I group

Experimental group

Description:

Sevoflurane will be given before the cerebral artery clip as a preconditioning procedure for the coming ischemia-reperfusion injury.

Treatment:

Procedure: Sev-I group