the New Biomarker of the Knee Osteoarthritis Knee Osteoarthritis Occurrence and Progression

Shihezi University

Status: Completed

Conditions: Knee Osteoarthritis

Treatments: Radiation: x-ray images

Study type: Observational

Funder types: Other

Identifiers

NCT03015688

2012-06-01

Details and patient eligibility

About

It was previously proved an association of TGF-β1 and PDGF-BB with the pathogenesis of osteoarthritis (OA) by experiments of OA animal models. In this study, we aimed to determine whether serum concentrations of TGF-β1, PDGF-BB and CTX-1 were related to the knee OA. knee OA cases were collected from the first affiliated hospital of Shihezi university and healthy controls were recruited from the community. The severity of knee OA was defined as kellgren-lawrence (K-L) classification criteria.Serum levels of chemical biomarkers were compared between knee OA cases and controls or among K-L grade 2 to grade 4 groups. The serum concentrations of the TGF-β1, PDGF-BB and CTX-1 were determined by ELISA .

Enrollment: 460 patients

Sex: All

Ages: 38 to 78 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• OA diagnosis was on the basis of the diagnosis and treatment guideline of the American Academy of Orthopedic Surgeons

Exclusion criteria

Participants who met the following criteria were excluded：

• the knee OA concomitant with hip OA,
• suppurative and rheumatoid arthritis,
• gout patients,
• patients who underwent knee arthroscopy surgery within 6 months,
• bilateral or unilateral knee replacements,
• the knee joint trauma patients,
• histories of glucocorticoid and/or sterol hormones.

Trial design

460 participants in 2 patient groups

knee OA

Description:

OA diagnosis was on the basis of the diagnosis and treatment guideline of the American Academy of Orthopedic Surgeons Participants who met the following criteria were excluded：the knee OA concomitant with hip OA, suppurative and rheumatoid arthritis, gout patients, patients who underwent knee arthroscopy surgery within 6 months, bilateral or unilateral knee replacements, the knee joint trauma patients, histories of glucocorticoid and/or sterol hormones.

Treatment:

Radiation: x-ray images

Control

Description:

"no often have pain, aching or stiffness in your Left/right knee during last month","no Left/right knee trauma history","no histories of glucocorticoid and/or sterol hormones" normal knee X-ray images,

Treatment:

Radiation: x-ray images