The Norepinephrine Transporter: A Novel Target for Imaging Brown Adipose Tissue

Yale University

Status and phase: Completed; Early Phase 1

Conditions: Brown Adipose Tissue

Treatments: Radiation: PET imaging

Study type: Interventional

Funder types: Other

Identifiers

NCT02038595

1008007284

Details and patient eligibility

About

This study seeks to assess a novel imaging technique to image brown adipose tissue utilizing the norepinephrine transporter.

Enrollment: 10 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age 18-30 yrs
• BMI < 24 kg/m2
• Caucasian

Exclusion criteria

• Current neuro-psychiatric illness
• substance abuse
• medical or neurological illnesses likely to affect physiology or anatomy, i.e., uncontrolled hypertension, cardiovascular disorders
• current pregnancy
• current breast feeding
• suicidal ideation or behavior
• use of medications which potentially affect NET binding within 2 weeks of the PET scans.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Healthy subjects

Experimental group

Description:

Healthy subjects (male, female)

Treatment:

Radiation: PET imaging