The Number and Function of Regular T Cell in Patients With Obstructive Sleep Apnea

Taipei Veterans General Hospital

Status: Unknown

Conditions: Sleep Apnea Syndromes

Treatments: Biological: OSA

Study type: Observational

Funder types: Other

Identifiers

NCT02342028

2015-01-005AC

Details and patient eligibility

About

To compare the number and function of regular T cell of patients with obstructive sleep apnea (OSA) versus that of age-, gender- and BMI (body mass index)-matched controls

Full description

Patients with obstructive sleep apnea (OSA) experience intermittent hypoxemia and arousal during sleep due to recurrent collapse of upper airway. Epidemiologic evidence showed they were at higher risk for autoimmune diseases. The regular T cell (Treg) has a crucial role in controlling autoimmunity. In this study, 40 OSA patients and 40 age-, gender- and BMI-matched controls will be recruited. Peripheral venous blood of the participants is drawn for numeration of CD4+CD25+FoxP3+ regular T cells by flow cytometry. As well, the CD4+CD25+ regular T cells are enriched by MACS and tested for their suppressive functions on proliferation assays. Th12+ CD4+ cells are also measured.

Enrollment: 80 estimated patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. OSA patients diagnosed with a polysomnography
2. Agree to participate the study and sign informed consent

Exclusion criteria

1. Do not agree to participate the study and sign informed consent
2. Has received any treatment or OSA
3. With major comorbidities (such as a diabetes, heart disease, lung diseases, renal diseases, autoimmune diseases, but hypertension excluded)
4. History of sarcoidosis and tuberculosis
5. On treatment of steroid and immunosuppressant

Trial design

80 participants in 2 patient groups

OSA

Description:

The study group enrolled patients with OSA, fulfilling the following requirements 1. 20\~60 years ago, female or males 2. Agree participate the study and sign informed consent 3. Has not received any treatment for OSA 4. No obvious comorbidities (including autoimmune diseases) 5. No history of sarcoidosis and tuberculosis 6. No use of steroid and immunosuppressant

Treatment:

Biological: OSA

Control

Description:

The control group enrolled age-, gender- and BMI-matched individuals without OSA, fulfilling the following requirements 1. 20\~60 years ago, female or males 2. Agree participate the study and sign informed consent 3. No obvious comorbidities (including autoimmune diseases) 4. No history of sarcoidosis and tuberculosis 5. No use of steroid and immunosuppressant