The Obese Taste Bud Study (OTB)

University of Leipzig

Status: Unknown

Conditions: Obesity

Treatments: Other: questionnaires; Diagnostic Test: Taste sensitivity; Other: biospecimen collection; Diagnostic Test: oral glucose tolerance test; Diagnostic Test: olfactory function; Diagnostic Test: anthropometry; Diagnostic Test: taste bud density; Procedure: taste bud biopsy

Study type: Observational

Funder types: Other

Identifiers

NCT04633109

OTB-2020

DRKS00022950 (Registry Identifier)

Details and patient eligibility

About

The sense of taste is essential for priming food preferences and is therefore important for caloric uptake and body weight regulation. Recent studies show that obesity is linked to changes in taste sensation but also to a loss of taste buds on the tongue. This study aims to evaluate underlying mechanisms within the taste buds to potentially influence the sense of taste on the level of these sensory cells and in order to develop new treatment strategies to fight obesity.

Enrollment: 210 estimated patients

Sex: All

Ages: 18 to 69 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• normal weight (BMI 18.5-24.9)
• obesity (BMI >=30)
• overall healthy (no severe sickness, no cancer)
• written informed consent

Exclusion criteria

• current pregnancy or currently breastfeeding
• cancer or tumors
• state after radiotherapy at head-neck area
• state after or current chemotherapy
• severe psychiatric-, cardiac-, kidney- or neurological illness
• diagnosed diabetes mellitus
• known dysfunction of smelling or tasting
• drug or alcohol abuse
• permanent medication with antidepressants, anticonvulsants, steroids and/or immunosuppressants

Trial design

210 participants in 2 patient groups

normal weight

Description:

Normal weight adults with BMI ranging from 18.5-24.9; men and women; age range 18-69years; written informed consent

Treatment:

Diagnostic Test: Taste sensitivity

Other: biospecimen collection

Other: questionnaires

Diagnostic Test: anthropometry

Diagnostic Test: taste bud density

Diagnostic Test: oral glucose tolerance test

Procedure: taste bud biopsy

Diagnostic Test: olfactory function

obese

Description:

Subjects with obesity as defined by BMI \>= 30; men and women; age range 18-69 years; written informed consent

Treatment:

Diagnostic Test: Taste sensitivity

Other: biospecimen collection

Other: questionnaires

Diagnostic Test: anthropometry

Diagnostic Test: taste bud density

Diagnostic Test: oral glucose tolerance test

Procedure: taste bud biopsy

Diagnostic Test: olfactory function