The Oil, Fats and Oleogel Study (OFO)

Clinical Nutrition Research Centre, Singapore

Status: Completed

Conditions: Glycaemic Response and Energy Balance

Treatments: Other: Congee and juice with coconut oil; Other: Congee and juice with sunflower gel; Other: Congee and juice with sunflower oil; Other: Congee and juice with coconut gel

Study type: Interventional

Funder types: Other

Identifiers

NCT02702726

2015/01093

Details and patient eligibility

About

The aim of this study is to compare the effects of dietary fats, ingested in two physical forms, on acute energy balance, appetitive, and glycemic responses of healthy normal (BMI 18-24.9 kgm-2) or overweight (BMI>25kgm-2) adults.

Full description

This will be a randomised, crossover study. Randomisation will be performed with an online randomisation software (www.randomizer.org). Participants will be screened (1 screening visit) and attend five test visits conducted in a whole room calorimeter (WRC). During each test visit, participants will arrive at the laboratory after an overnight fast, enter the WRC and rest for 15 minutes in a supine position,have their resting energy expenditure (REE) measured for 30 minutes and consume congee and juice alone(control), or with one of the 4 dietary fats: sunflower oil (SO) or gel (SG) and coconut oil (CO) or gel (CG) (total 5 test visits). Post-meal energy expenditure, fat oxidation, glycemia and appetite (visual analog scales) will be measured continuously for 3 hours in WRC, followed by a meal challenge where participants will eat until sated. Participants will return and repeat the protocol until all fat types and forms are completed.

Enrollment: 16 patients

Sex: Male

Ages: 21 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Exclusion Criteria:

• People with major chronic disease such as heart disease, cancer, hypertension or diabetes mellitus
• People with known food allergies, due to potential traces of allergens found in the commercially available food product used in our study (Knorr's instant congee)
• People who are claustrophobic
• Individuals who are taking insulin or drugs known to affect glucose metabolism, appetite, and body fat distribution
• Have weight change of >5kg in the past 3 months
• People with a major medical or surgical event requiring hospitalization within the preceding three months
• People who are on a weight loss regime
• Individuals with the presence of disease or drugs which influence digestion and absorption of nutrients

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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16 participants in 5 patient groups

Congee and juice only

No Intervention group

Description:

Control breakfast providing 50g carbohydrate

Congee and juice with coconut gel

Active Comparator group

Description:

Control breakfast, plus 25g coconut oleogel (solid)

Treatment:

Other: Congee and juice with coconut gel

Congee and juice with coconut oil

Active Comparator group

Description:

Control breakfast, plus 25g coconut oil (liquid)

Treatment:

Other: Congee and juice with coconut oil

Congee and juice with sunflower gel

Active Comparator group

Description:

Control breakfast, plus 25g sunflower oleogel (solid)

Treatment:

Other: Congee and juice with sunflower gel

Congee and juice with sunflower oil

Active Comparator group

Description:

Control breakfast, plus 25g sunflower oil (liquid)

Treatment:

Other: Congee and juice with sunflower oil