The Ontario Multi-Regional Hospital COVID-19 Registry (COREG)- Recovery Trajectory Sub-study

Hamilton Health Sciences (HHS)

Status: Unknown

Conditions: COVID-19 Pneumonia; Sars-CoV-2 Infection

Treatments: Diagnostic Test: CT scan; Diagnostic Test: Pulmonary Function Test

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT04868864

13161

Details and patient eligibility

About

Radiological and lung function recovery following Covid-19 infection.

Full description

The investigators propose to conduct pulmonary LDCT imaging and physiological lung function assessments, and combine this with detailed multi-regional hospitalization clinical data collection on COVID-19 cases (COREG registry); to inform long-term pulmonary and extra-pulmonary consequences and the recovery trajectory following COVID-19 infection.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients discharged from hospital post COVID-19 infection who have radiographic and clinical evidence of COVID-19 pneumonia during hospitalization.
• Patients with evidence of unresolved radiographic changes or persistent hypoxemia.

Exclusion criteria

• Failure to comply with study procedures.

Trial design

200 participants in 2 patient groups

Moderate to severe COVID-19 infection

Description:

COVID-19 patients with radiographic changes on CXR or CT which had not resolved or had persistent hypoxia due to COVID-19 at the time of discharge will be enrolled. All participants will undergo a LDCT and PFT.

Treatment:

Diagnostic Test: CT scan

Diagnostic Test: Pulmonary Function Test

Persistent LDCT or PFT abnormalities

Description:

Participants with abnormalities on LDCT and or PFT will be invited to continue with a follow-up sub-study. This will involve follow up with repeated LDCT and PFT at subsequent time points to monitor and manage the abnormalities detected until the abnormalities fully resolve or to the last time point at 9 months of the study.

Treatment:

Diagnostic Test: CT scan

Diagnostic Test: Pulmonary Function Test