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The Optimization of Blood Pressure and Fluid Status Control With Eight-Polar Bioelectrical Impedance Analysis

T

Taipei Veterans General Hospital

Status and phase

Completed
Phase 4

Conditions

Hypertension
Heart Diseases
Fluid Overload

Treatments

Device: Bioelectrical impedance-guide dry weight reduction

Study type

Interventional

Funder types

Other

Identifiers

NCT00852514
VGHIRB 95-08-28A

Details and patient eligibility

About

Peritoneal dialysis (PD) is a widely used modality of renal replacement therapy. Due to its continuous nature of therapy, better control of fluid status and preservation of residual renal function were presumed by most nephrologists. However, recent evidences showed that it might not be the case. The severity of fluid overloading and the need for anti-hypertensive agents to control blood pressure seems to be more severe for PD patients. Therefore, more aggressive strategy to control dry weight is mandatory in PD patients. However, over reduction of dry weight might affect residual renal function (RRF) and, probably, the survival of PD patients. A balance between reduction of dry weight and preservation of RRF is crucial for the care of PD patients. Currently, only clinical measures like cardiothoracic ratio on chest X-ray and absence of pedal edema were used to evaluate PD patient's dry weight. There is no objective method to determine dry weight accurately. In this prospective and randomized study, the investigators will use multi-frequency bio-impedance (MF-BIA) to detect intracellular and extracellular water (ECW) content of patients.

Enrollment

132 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • age 18 to 80

Exclusion criteria

  • type I DM
  • Severe heart failure
  • unstable angina

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

132 participants in 1 patient group

Monthly BIA
Experimental group
Description:
monthly BIA to monitor fluid status
Treatment:
Device: Bioelectrical impedance-guide dry weight reduction

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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