The Optimization of Procedural Pain Control in Intensive Care Unit (ICU) Patients (OPCIC)

St. Antonius Hospital

Status

Completed

Conditions

Critical Illness

Treatments

Drug: morphine

Study type

Interventional

Funder types

Other

Identifiers

NCT00558090

R-07.15A/OPCIC

NL18828.100.07

Details and patient eligibility

About

The purpose of this study is to determine the influence of morphine 2,5 mg or morphine 7,5 mg iv during a painful and unavoidable intervention in critically ill patients.

Full description

In 2006, in the Intensive Care Unit (ICU) of the St. Antonius Hospital an analgesia improvement program has been implemented. This program consisted of training of ICU nurses and intensivists using a hospital based standardized pain protocol, and systematic pain measurements in rest, rated by the patient himself whenever possible or otherwise by the attending nurse. This program has resulted in a reduction of severe pain levels (NRS≥4) in ICU patients in rest from 41% to 22%. In order to further reduce this percentage, a pain titration protocol is introduced in 2007. As no attention has yet been paid to intervention-related pain levels in these patients, in this prospective study pain control will be studied using different analgesic dosages of morphine iv (2,5 mg vs 7,5 mg) around unavoidable painful interventions within a pain titration protocol for pain control in rest.

Enrollment

150 estimated patients

Sex

All

Ages

18 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients admitted to the ICU of the St. Antonius hospital, between 18-85 years old en weighing between 45-140 kg.

Exclusion criteria

Pregnancy/ breastfeeding
Language barrier
Known morphine iv allergy
Comatose patients (cooled)
Patients who are suspected to be brain-dead
Unintubated patients on the verge of intubation due to respiratory insufficiency