The Paternal Clock: Uncovering the Consequences of Advanced Paternal Age on Sperm DNA Fragmentation

Ovo Clinic

Status: Completed

Conditions: Infertility, Male

Treatments: Other: Study chart review

Study type: Observational

Funder types: Industry

Identifiers

NCT05894356

3287

Details and patient eligibility

About

Sperm DNA fragmentation (SDF) serves as a marker for chromatin and DNA damage in sperm. Assessing sperm DNA integrity is crucial in male fertility evaluation since high levels of SDF are associated with a greater number of adverse reproductive outcomes, including an increased risk of miscarriage and birth defects.

Recent research suggests that advanced paternal age (APA) may lead to DNA damage in sperm, however the precise age at which this risk becomes apparent has not yet been clearly defined, necessitating the identification of the point in time at which high SDF levels occur. With the help of this knowledge, male infertility can be diagnosed with greater accuracy, and infertile couples can receive appropriate care.

Enrollment: 4,250 patients

Sex: Male

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Male of at least 18 years of age

Trial design

4,250 participants in 1 patient group

Men undergoing sperm DNA fragmentation test

Description:

Men presenting at the clinic for infertility evaluation

Treatment:

Other: Study chart review