The Pathogenesis of Human Senile Cataract

Shanghai Jiao Tong University

Status: Unknown

Conditions: Cataract

Treatments: Procedure: phacoemulsification

Study type: Observational

Funder types: Other

Identifiers

NCT03907358

Shanghai1st-cataract-001

Details and patient eligibility

About

To study the pathological mechanism of cataract by genomics, transcriptomics, and proteomics.

Full description

Tissue samples and aqueous humor samples will be collected from each individual patients by cataract surgery. After sample treatment, different techniques will be applied for analysis. And bioinformatics approach is applied for data treatment and analysis.The data of genomics, transcriptomics, and proteomics will be analyzed for study of pathological mechanism of cataract.

Enrollment: 20 estimated patients

Sex: All

Ages: 5 to 94 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with the explicit diagnosis of cataract (including senile cataract, congenital cataract, complicated cataract, metabolic cataract, traumatic cataract, etc.) in the operated eye are willing to undergo cataract surgery.

Exclusion criteria

• Patients whose cataracts need not be operated
• Patients with any contraindications to cataract surgery
• Patients are unwilling to undergo cataract surgery

Trial design

20 participants in 2 patient groups

cataract in old age

Treatment:

Procedure: phacoemulsification

cataract in young age

Treatment:

Procedure: phacoemulsification