The PENTO Protocol in Medication-related Osteonecrosis of the Jaw

University of Limoges (UL)

Status and phase

Enrolling

Phase 2

Conditions

Medication-related Osteonecrosis of the Jaw (MRONJ)

Treatments

Drug: Pentoxifylline+Tocopherol

Study type

Interventional

Funder types

Other

Identifiers

NCT05795647

87RI21_0052 (PENTO)

Details and patient eligibility

About

Medication-related osteonecrosis of the jaw (MRONJ) occurs after taking bisphosphonates or targeted therapies. It leads to a significant decrease in quality of life with pain, eating and chewing disorders, and malnutrition. Current treatments are only partially effective. PENTO (pentoxifylline and tocopherol) has been shown to be effective in maxillary osteoradionecrosis. The objective of this study is to evaluate the proportion of bone recovery in patients receiving PENTO in MRONJ at 12 months.

Full description

MRONJ is defined as intraoral bone exposure persisting for more than 8 weeks after taking an anti-resorptive agent (per os or IV bisphosphonates, targeted therapies) and without history of maxilla radiotherapy or metastasis. It leads to a significant decrease in quality of life with significant pain at rest and during mastication, and compromised nutrition, sometimes resulting in severe undernutrition in patients already weakened by a history of cancer. Current treatments (prolonged antibiotic therapy, repeated bone curettage) have shown partial effectiveness. PENTO (combination of pentoxifylline, a vasodilator, and tocopherol, vitamin E) has been shown to significantly reduce intraoral exposed bone surface area and pain in maxilla osteoradionecrosis. All studies conducted so far on PENTO in MRONJ are retrospective or involve small samples. Therefore, our idea is to perform a well-conducted prospective phase IIa study to prove the efficacy of PENTO, with a larger sample size and identical follow-up periods. The investigators will study patients with AAOMS stage 2 MRONJ (exposed bone in symptomatic patients, without pathologic fracture).

Treatment will consist of pentoxifylline LP 400 mg morning and evening, combined with tocopherol 500 mg morning and evening. Antibiotic therapy with Augmentin (or clindamycin) will be added for the first month and then punctually if signs of local infection appear.

The primary and secondary endpoints will be assessed at inclusion and at 1, 3, 6 and 12 months.

Enrollment

17 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age greater than or equal to 18 years
Current or past treatment with bisphosphonates (oral or IV) and/or targeted therapies (denosumab, bevacizumab)
Signs and symptoms for more than 8S with confirmation that the signs and symptoms are not of dental origin
AAOMS Stage 2 MRONJ
For patients of childbearing age, effective contraception is required

Exclusion criteria

History of head or neck radiotherapy or maxilla metastases
Patients who have received treatment in the past (PENTO or PENTOCLO protocol)
Patients who have undergone surgery for their MRONJ within the last 3 months
Pregnant or wishing to be pregnant, breastfeeding
Patient under palliative care
Patient with hypersensitivity to pentoxifylline or tocopherol or to an excipient
History of hypersensitivity reaction to penicillins, cephalosporins, or other beta-lactams (and clindamycin or lincomycin if applicable) or excipient of amoxicillin-a. clavulanic or clindamycin
History of jaundice/hepatic injury related to amoxicillin/clavulanic acid
Patient taking oral anticoagulants, or with a history of major bleeding or bleeding disorders
Patient taking platelet aggregation inhibitor, theophylline or aminophylline
Patient taking methotrexate, probenecid, mycophenolate mofetil, myorelaxant drugs, macrolide or streptogramin antibiotics
Patients with hepatic failure or renal failure (Cl < 30 mL/min),
Patient with hypotension (SBP < 90 mmHg)
Refusal to participate in the study
Patient participating in other interventional research that may interfere with the conduct of this research
Patient unable to understand the protocol
Patient under curatorship or guardianship