The PERFusion Use in Stroke Evaluation Study (PERFUSE)

California Pacific Medical Center Research Institute

Status: Completed

Conditions: Ischemic Stroke

Treatments: Other: Computed tomography perfusion imaging

Study type: Observational

Funder types: Other

Identifiers

NCT01387113

PERFUSE

Details and patient eligibility

About

This is an open label single center phase II trial, evaluating the utility of 64 slice CT perfusion (CTP) in acute ischemic stroke (AIS) patients. The main aim is to determine which aspects of CTP imaging can aid in expanding the time window for thrombolysis with IV (rt-PA) in AIS patients up to 6 hours after symptom onset.

Enrollment: 48 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Acute ischemic stroke
• ≥ 18 years old
• presentation up to 6 hours from time of onset of acute stroke symptoms

Exclusion criteria

• pregnancy
• inability to receive CT scan
• allergy to IV contrast
• symptoms with full resolution
• intracerebral hemorrhage
• severe stroke which is classified as 'malignant' (hypodensity on noncontrast CT greater than 1/3 cerebral hemisphere)
• premorbid mRS of >3
• life expectancy of ≤3 months
• any condition which, in the opinion of the investigator makes the subject unsuitable for study

Trial design

48 participants in 1 patient group

Acute ischemic stroke patients

Description:

All acute ischemic stroke patients receiving IV rt-PA within 6 hours of symptom onset

Treatment:

Other: Computed tomography perfusion imaging