The Physical Dosimetry Study and Preliminary Clinical Results of 3D-printing Non Co-planar Template Assisted With CT-guidance for Iodine-125 Seed Brachytherapy in Pelvic Recurrent Rectum Carcinoma After Surgery and External Beam Radiotherapy

P

Peking University

Status

Completed

Conditions

Rectum Cancer, Recurrent
Brachytherapy, Radioisotope

Treatments

Radiation: radioactive Iodine-125 seed implantation under the guidance of 3D template

Study type

Observational

Funder types

Other

Identifiers

NCT03890926
PekingUTH RT

Details and patient eligibility

About

This study observes the efficacy and side effects of 3D-printing non co-planar template(3D-PNCT) assisted with CT-guidance for radioactive Iodine-125 seed(RIS) brachytherapy in pelvic recurrent rectum carcinoma retrospectively, and analyzes the influence of clinical and dosimetric factors on the outcomes.

Full description

3D-PNCT assisted with CT-guidance for radioactive Iodine-125 seed brachytherapy is a conventional treatment in Peking University Third Hospital. Radioactive Iodine-125 seed brachytherapy is the implantation of Iodine-125 seed into tumors.The radioactive Iodine-125 seed can release low dose of irradiation persistently which kills tumors cell and causes less damage to normal tissue at the same time. 3D-printing non co-planar template is made individually which guides the implantation of Iodine-125 seed into the tumor and ensures the accuracy of the position.This study collects the data of patients with pelvic recurrent rectal carcinoma who underwent 3D-PNCT assisted with CT-guidance for radioactive Iodine-125 seed implantation from 2015 to 2018. We evaluate the dose that covers 90% target volume(D90),the volume that 100% prescription dose covers(V100) and other dosimetric parameters after the implantation. The efficacy and adverse effects were observed. Local control(LC) time and overall survival(OS) time are evaluated.

Enrollment

66 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • treated with 3D-printing non co-planar template assisted with CT-guidance for Iodine-125 seed brachytherapy in Peking University Third Hospital
  • histological proven recurrent rectal cancer
  • inoperable local recurrent cases
  • previous external beam radiotherapy, incapable of re-irradiation
  • expected life span>3 months

Exclusion criteria

  • serious medical illness
  • unable to tolerate anesthesia
  • blood coagulation dysfunction

Trial design

66 participants in 1 patient group

radioactive Iodine-125 seed implantation
Description:
All enrolled patients received the intervention previously as a conventional treatment.
Treatment:
Radiation: radioactive Iodine-125 seed implantation under the guidance of 3D template

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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