The Physiological Consequence of Silicone-hydrogel Care-solution Bio-incompatibility

Southern California College of Optometry at Marshall B. Ketchum University

Status

Completed

Conditions

Contact Lens Solution Toxicity

Treatments

Device: PureVision lenses soaked in OptiFree RePlenish

Device: PureVision lenses soaked in ReNu Multiplus

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00829751

08-8

Details and patient eligibility

About

The purpose of this study is to more objectively evaluate potential lens-material/care solution bio-incompatibilities. We will do this by measuring corneal staining and the amount of fluorescein dye diffusion into the eye.

Enrollment

26 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

At least 18 years of age.
Best correctable vision to 20/40 in each eye.
Possess a functional spectacle prescription to allow adequate vision during the de-adaptation and fluorometry measurement period.
No known ocular or systemic allergies, which may interfere with contact lens wear.
No known systemic disease, or need for medication that may interfere with contact les wear (i.e. antihistamines, beta-blockers, steroids, ect.).

Exclusion criteria

Subjects demonstrating any medical condition that may affect the results of this study SHOULD NOT be enrolled. The following are specific conditions that exclude subjects from enrollment in this study.
Eye (ocular) or systemic allergies that may interfere with contact lens wear.
Clinically significant corneal swelling (greater than 3 or 4 on a 0-4 scale), corneal blood vessel growth (vascularization), corneal staining, bulbar redness, tarsal redness, or any other abnormality of the cornea that may cause unsafe contact lens wear.
Are taking part in any other study or have taken part in a study within the last 14 days.
Are pregnant, or anticipating to become pregnant during the course of the study.