The Physiological Effect of High Flow Oxygen Therapy

Guangzhou Medical University

Status: Unknown

Conditions: Non-invasive Positive Pressure Ventilation; High-flow Nasal Cannula; Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Treatments: Device: HFNC; Device: NPPV

Study type: Interventional

Funder types: Other

Identifiers

NCT04212182

GIRH-HFNC8306

Details and patient eligibility

About

Although non-invasive positive pressure ventilation (NPPV) shows the good curative effect of treating the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), some patients do not tolerate NPPV or do not benefit from it. High-flow nasal cannula (HFNC) is well tolerated and may be used to patients with AECOPD who are intolerant to NPPV treatment. This study is to evaluate the physiological effect of HFNC and compare it with NPPV.

Enrollment: 10 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• AECOPD patients with acute hypercapnic respiratory failure

Exclusion criteria

• other lung/pleural diseases or thoracic deformity
• severe heart failure (New York Heart Association class IV), severe dysrhythmia
• unstable angina, or malignant comorbidity
• obesity (BMI ≥ 35 kg/m²)
• severe obstructive sleep apnea syndrome

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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10 participants in 2 patient groups

HFNC group

Experimental group

Description:

AECOPD patients receive ventilation support via HFNC.

Treatment:

Device: HFNC

NPPV group

Active Comparator group

Description:

AECOPD patients receive ventilation support via NPPV.

Treatment:

Device: NPPV