The Physiological Effect of RCexp on Ventilation/Perfusion Distribution

Southeast University, China

Status: Enrolling

Conditions: Acute Respiratory Distress Syndrome; Mechanical Ventilation

Treatments: Other: RCexp

Study type: Observational

Funder types: Other

Identifiers

NCT06919484

RCexp_ventilation/perfusion

Details and patient eligibility

About

With the exception of setting the positive end-expiratory pressure (PEEP), the expiratory phase is commonly overlooked during MV. The expiratory time constant (RCexp) plays an important role in understanding the mechanical properties of the respiratory system in patients receiving mechanical ventilation. However, it is unclear that the effect of expiratory time constant on the ventilation and perfusion distribution.

Full description

With the exception of setting the positive end-expiratory pressure (PEEP), the expiratory phase is commonly overlooked during MV. The expiratory time constant (RCexp) plays an important role in understanding the mechanical properties of the respiratory system in patients receiving mechanical ventilation. However, it is unclear that the effect of expiratory time constant on the ventilation and perfusion distribution.

Enrollment: 60 estimated patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

adult patients with ARDS receiving mechanical ventilation no more than 72 hours

Exclusion criteria

1. age <18 years old
2. patient undergoing legal protection
3. contra-indications to EIT (e. g. severe chest trauma or wounds)
4. pneumothorax
5. patient undergoing ECMO
6. pregnancy

Trial design

60 participants in 1 patient group

mechanically ventilated patients with ARDS

Treatment:

Other: RCexp