The Possible Effect Of Amniotic Fluid pH On Neonatal Morbidities In Maternal Inflammation/Infection Associated Pregnancies

Kanuni Sultan Suleyman Training and Research Hospital

Status: Completed

Conditions: Intrauterine Growth Retardation; Respiratory Distress Syndrome; Transient Tachypnea of Newborn

Treatments: Device: Amniotic fluid analysis by blood gas device

Study type: Interventional

Funder types: Other

Identifiers

NCT02691559

1

Details and patient eligibility

About

Amniotic fluid (AF) pH can be affected by the maternal and/or fetal conditions such as PPROM, prematurity or fetal distress. It is known that fetal urine is the major content of AF since 20th gestational week. Besides fetal alveolar fluid (FAF), gastrointestinal tract, umbilical cord and fetal side of placenta are important sources for AF. Bombesin-like peptides, 8-hydroxydeoxyguanosine in fetal urine and leukotriene E(4), lecithin, sphingomyelin, lamellar body in FAF are molecules acting on fetal lung maturation. Varying levels of these molecules relevant to the stage of lung maturation may constitute an association to AF pHTo detect the possible effect of AF pH on neonatal respiratory morbidities 1 milliliters of AF is aspirated during C-section before incision of membranes. pH value of AFs were analyzed by the blood gas machine (Siemens RAPIDLab®1200 Systems) of NICU. Maternal and neonatal demographic features and clinical outcomes, incidences of morbidities such as respiratory distress syndrome (RDS), transient tachypnea of the newborn (TTN) are all recorded.

Enrollment: 184 patients

Sex: All

Ages: Under 5 minutes old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Inflammation/infection associated pregnancies Normal healthy pregnancies

Exclusion criteria

Congenital abnormalities Chromosomal abnormalities Blood contaminated amniotic fluid

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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184 participants in 2 patient groups

maternal inflammation group

Active Comparator group

Description:

Amniotic fluid analysis by blood gas device: evaluate the possible association between maternal inflammation and amniotic fluid pH two groups will be designed. One group will consist of infants born to mothers with infection/inflammation whereas the control group will consist of infants born to mothers without infection/inflammation. In all deliveries amniotic fluid will be taken and will be analyzed by blood gas device.

Treatment:

Device: Amniotic fluid analysis by blood gas device

normal pregnancy group

Active Comparator group

Description:

Amniotic fluid analysis by blood gas device: The control group will consist of infants born to mothers without infection/inflammation. In all deliveries amniotic fluid will be taken and will be analyzed by blood gas device.

Treatment:

Device: Amniotic fluid analysis by blood gas device