The Potential Biochemical Diagnosis Criteria and Therapeutic Effect Indexes: Sex Hormone Binding Globulin Levels and Free Androgen Index in Blood of Patients With Polycystic Ovary Syndrome

Z

Zhongshan Bo Ai Hospital

Status

Completed

Conditions

At the Same Time, the Investigators Continuedly Collect Cases to October 2012, and Totally Collected 579 Patients With PCOS Altogether;
The Investigators Collected 534 PCOS Patients as the Case Group,and 580 Infertile Women With Normal Ovulatory Cycle of the Control Group;
534 Patients in the Cases Group and 580 Women in the Control Group Received no Measures, While 579 Patients Received Drugs;
The Investigators Monitored Basic Indexes in Blood of All the Subjects in This Suvey,and Also Monitored Indexes of 579 Patients After Treatment.

Treatments

Drug: Diane-35;metformin;Clomiphene citrate; Human menopausal gonadotropin

Study type

Observational

Funder types

Other

Identifiers

NCT01784380
2006A165

Details and patient eligibility

About

To explore whether Free androgen index(FAI)can be regarded as biochemically diagnostic indexes of high androgen hormone in blood of patients with Polycentric ovary syndrome(PCOS). Also to explore whether Sex hormone-binding globulin(SHBG) and FAI can be seen as therapeutic effect indicatrixes of women with PCOS.

Enrollment

1,159 patients

Sex

Female

Ages

20 to 43 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • The clinical diagnosis criteria for PCOS by European Society of Human Reproduction and Embryology, and Rotterdam working group of American Society for Reproductive Medicine (ESHRE /ASRM )

Exclusion criteria

  • hyperprolactinemia and other endocrine diseases such as high androgen hormone in blood, namely Cushing's syndrome, congenital adrenal hyperplasia ( CAH ), ovarian or adrenal tumor and so on

Trial design

1,159 participants in 3 patient groups

the case group
the control group
the treatment group
Description:
Patients of the treatment group recieved drugs,then we observed drugs' treatment effect.
Treatment:
Drug: Diane-35;metformin;Clomiphene citrate; Human menopausal gonadotropin

Trial contacts and locations

2

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Data sourced from clinicaltrials.gov

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