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The Potential Role for Adenosine in the Haemodynamic Effects of Free Fatty Acids

R

Radboud University Medical Center

Status

Completed

Conditions

Obesity
Metabolic Syndrome X

Treatments

Drug: Intravenous infusion of Glycerol/heparin
Drug: Intravenous infusion of Intralipid/heparin

Study type

Interventional

Funder types

Other

Identifiers

NCT00184899
ZonMw Nr. 920-03-249
Intralipid-Ado

Details and patient eligibility

About

The metabolic syndrome is associated with hyperdynamic circulation and sympathetic activation. Recently, Bakker et al. (Atherosclerosis 2002) described the hypothesis that free fatty acids are responsible for this association. The investigators hypothesize that in patients with obesity and the metabolic syndrome, an increased intracellular concentration of long-chain fatty acyl (LCFA)-CoA (the intracellular equivalent of free fatty acids) induces an increase in adenosine. Adenosine receptor stimulation, in turn, induces vasodilation and sympathetic activation.

The investigators aimed to assess this effect of free fatty acids on the adenosine system in healthy volunteers.

Sex

All

Ages

18 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy volunteers

Exclusion criteria

  • Pregnancy
  • Asthma
  • Use of medication
  • Cardiovascular/pulmonary disease and diabetes

Trial design

Primary purpose

Educational/Counseling/Training

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Single Blind

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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