The Potential Role for Adenosine in the Haemodynamic Effects of Free Fatty Acids

Radboud University Medical Center

Status: Completed

Conditions: Obesity; Metabolic Syndrome X

Treatments: Drug: Intravenous infusion of Glycerol/heparin; Drug: Intravenous infusion of Intralipid/heparin

Study type: Interventional

Funder types: Other

Identifiers

NCT00184899

ZonMw Nr. 920-03-249

Intralipid-Ado

Details and patient eligibility

About

The metabolic syndrome is associated with hyperdynamic circulation and sympathetic activation. Recently, Bakker et al. (Atherosclerosis 2002) described the hypothesis that free fatty acids are responsible for this association. The investigators hypothesize that in patients with obesity and the metabolic syndrome, an increased intracellular concentration of long-chain fatty acyl (LCFA)-CoA (the intracellular equivalent of free fatty acids) induces an increase in adenosine. Adenosine receptor stimulation, in turn, induces vasodilation and sympathetic activation.

The investigators aimed to assess this effect of free fatty acids on the adenosine system in healthy volunteers.

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers

Exclusion criteria

• Pregnancy
• Asthma
• Use of medication
• Cardiovascular/pulmonary disease and diabetes

Trial design

Primary purpose: Educational/Counseling/Training

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind