The Potential Role of Testosterone on Target Organ Damage in Postmenopausal Hypertensive Women

Lanzhou University

Status: Unknown

Conditions: Hypertension

Study type: Observational

Funder types: Other

Identifiers

NCT03451747

LanZhou

Details and patient eligibility

About

The incidence of CVD-related deaths is generally higher in women than men. Postmenopausal changes in estrogen/androgen ratio that induce a relative androgen excess have been proposed as important factors in the higher prevalence of hypertension. Therefore, the investigators hypothesize that testosterone has potential role between hypertension and target organ damage in postmenopausal hypertensive women. And the objective is to evaluate the effects of testosterone between hypertension and target organ damage in postmenopausal hypertensive women.

Enrollment: 322 estimated patients

Sex: All

Ages: 45 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of hypertension
• Women are all postmenopausal
• Men are matched with women.

Exclusion criteria

• Secondary hypertension
• Coronary disease
• Heart failure
• Arterial fibrillation
• Previous myocardial infarction
• Previous stroke
• Malignant disease
• Kidney failure
• Liver failure
• Neoplastic disease
• Severe neurological diseases
• Severe metabolic or organic decompensation
• Refuse to sign the informed consent form

Trial design

322 participants in 2 patient groups

postmenopausal hypertensive women

mached hypertensive men