The Predictive and Diagnostic Value of Cystatin C and High Sensitive Troponin

Ankara Diskapi Training and Research Hospital

Status: Unknown

Conditions: Chronic Kidney Diseases; Acute Coronary Syndrome

Treatments: Procedure: percutaneous coronary intervention

Study type: Observational

Funder types: Other

Identifiers

NCT05303441

AnkaraDiskapiTRH

Details and patient eligibility

About

Our study is planning to evaluate patients with chronic kidney disease who come to the emergency department with chest pain. Estimated GFR (cisGFR) with cystatin and estimated GFR (creaGFR) with creatinine will be calculated. Symptoms, ECG and troponin values of patients will be evaluated for diagnosis of acute coronary syndrome

Full description

Our study is planning to evaluate patients with chronic kidney disease who come to the emergency department with chest pain. Estimated GFR (cisGFR) with cystatin and estimated GFR (creaGFR) with creatinine will be calculated. Symptoms, ECG and troponin values of patients will be evaluated for diagnosis of acute coronary syndrome and the final diagnosis of AMI will be adjudicated by 2 independent cardiologists.Serial troponin measurements and eGFR values will be proportioned. These values the will be evaluated and compared for patients with acute coronary syndrome(culprit lesion on conventional coronary angiography) and non-ACS ones . With these data we aim to facilitate the diagnosis of acute coronary syndrome,increase the specificity and sensitivity of cardiac troponins for the diagnosis of acute coronary syndrome of patients with chronic kidney disease, increase the utility of high sensitive troponins for patients with chronic kidney disease. Again, with these data, it is aimed to reduce the number of false negative and false positive diagnosis of acute coronary syndrome .

Enrollment: 172 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age over 18,
2. chronic kidney diease having chest pain or equivalent of chest pain (dyspnea, diaphoresis, syncope, nausea, vomiting) -

Exclusion criteria

1. STEMI,
2. age less than 18,
3. missing data,
4. patients referred to or accepted from another medical facility

Trial design

172 participants in 2 patient groups

patients with acute coronary syndrome

Description:

patients with chronic kidney disease having chest pain with ecg, symptom or cardiac troponin levels compatible with ACS

Treatment:

Procedure: percutaneous coronary intervention

patients without acute coronary syndrome

Description:

patients with chronic kidney disease having chest pain with ecg, symptom or cardiac troponin levels NONcompatible with ACS