The Predictive Value of Doppler Based Renal Ultrasound and Urinary Oxygen Tension for Prediction of Acute Kidney Injury After Open Heart Surgery

Tanta University

Status: Enrolling

Conditions: Open Heart Surgery; Urinary Oxygen Tension; Acute Kidney Injury; Doppler-Based Renal Ultrasound

Treatments: Other: Renal Artery Pulsatility Index; Other: Renal resistive index; Other: Urinary oxygen tension (PUO2)

Study type: Observational

Funder types: Other

Identifiers

NCT07037485

36265MD279/9/24

Details and patient eligibility

About

This study aims to investigate the predictive value of Doppler-based renal ultrasound and urinary oxygen tension in the development of acute kidney injury after cardiac surgery.

Full description

Cardiac surgery-associated acute kidney injury (CSA-AKI) is a complication following cardiac surgery occurring in 15-30% of patients. It is associated with increased morbidity and mortality as well as prolonged hospital stay and higher medical costs.

The renal artery pulsatility index (RAPI), which is determined using Doppler measurements, has been reported to detect patients with a high risk of AKI. Additionally, the renal resistance index (RRI), measured by Doppler ultrasound, can accurately predict the occurrence of AKI.

Urinary oxygen partial pressure in the bladder has been shown to decrease in the setting of sepsis, reduced renal blood flow, and decreased cardiac output.

Enrollment: 50 estimated patients

Sex: All

Ages: 21+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age above 21 years.
• Both sexes.
• Undergoing elective on-pump cardiac surgery.

Exclusion criteria

• Patients with chronic kidney disease.
• Patients with any renal pathology or anatomic kidney abnormalities.
• Patients on renal replacement therapy.

Trial design

50 participants in 1 patient group

Study group

Description:

Patients undergoing elective on-pump cardiac surgery

Treatment:

Other: Urinary oxygen tension (PUO2)

Other: Renal resistive index

Other: Renal Artery Pulsatility Index