The Predictive Value of Lubricin in Patients With Infective Endocarditis

Aydin Adnan Menderes University

Status: Invitation-only

Conditions: Infective Endocarditis

Treatments: Diagnostic Test: Lubricin

Study type: Observational

Funder types: Other

Identifiers

NCT06266741

NCT093509350936

Details and patient eligibility

About

The main goal of this study is to evaluate the predictability of the disease by measuring the serum lubricin levels in patients with infective endocarditis and in non-patients

Full description

Infective endocarditis is a challenging disease with a wide range of clinical presentations, making it difficult to diagnose. Diagnosis primarily relies on clinical suspicion based on symptoms. Blood cultures or other microbial tests confirming the presence of infection and echocardiography are supportive diagnostic tools. Another marker that may become valuable in the near future for diagnosing infective endocarditis is Lubricin. Lubricin, a glycoprotein expressed by the PRG4 gene, has been found to have significantly elevated levels in the plasma of animals with damaged or infected heart valves compared to healthy animals. Furthermore, plasma lubricin levels can potentially serve as a biomarker in situations like endocardial injury and infection. Lubricin and Procalcitonin will be studied from the blood samples routinely collected. During this academic study, procalcitonin and lubricin values will be measured by investigators. Thus, the sensitivity and specificity of the Lubricin parameter in patients with infective endocarditis will be evaluated.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The patient must be between 18 and 65 years old
• Patients diagnosed with infective endocarditis according to the Duke criteria

Exclusion criteria

• The patient being pregnant

Trial design

60 participants in 2 patient groups

Patients with infective endocarditis

Description:

Patients between the ages of 18-65 diagnosed with infective endocarditis according to the Duke criteria

Treatment:

Diagnostic Test: Lubricin

Patients without infective endocarditis

Description:

Patients between the ages of 18-65 without diagnosed with infective endocarditis according to the Duke criteria

Treatment:

Diagnostic Test: Lubricin