The Predictive Value of Progesterone (PFRET)

Ghent University Hospital (UZ)

Status: Active, not recruiting

Conditions: Subfertility

Study type: Observational

Funder types: Other

Identifiers

NCT05876234

ONZ-2023-0223

Details and patient eligibility

About

To evaluate a 5 ng/ml serum progesterone (P4) threshold policy for the addition of subcutaneous (SC) P4 in artificially prepared frozen embryo transfer cycles treated with vaginal P4. We assess whether the addition of SC P4 rescues cycles with serum P4 <5 ng/ml and we study the impact of not supplementing cycles with serum P4 >5 ng/ml by comparing them with serum P4 cycles above the conventionally proposed cut-off of 10 ng/ml.

Enrollment: 3,000 estimated patients

Sex: Female

Ages: 18 to 47 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

• Embryo transfer between March 1st 2021 and March 31st 2023
• Determination of progesterone on the day of embryo transfer