The Presence Of Sarcopenia In Patients With Knee Osteoarthritis

Gaziler Physical Medicine and Rehabilitation Education and Research Hospital

Status

Completed

Conditions

Osteoarthritis

Sarcopenia

Treatments

Diagnostic Test: Isokinetic dynamometer

Diagnostic Test: Musculoskeletal ultrasound

Diagnostic Test: Dual-X-ray absorptiometry

Study type

Observational

Funder types

Other

Identifiers

NCT04828200

Details and patient eligibility

About

Osteoarthritis (OA) is one of the most common joint disorders worldwide . The knee is the most common symptomatic joint in osteoarthritis. In this study, we evaluated the presence of sarcopenia multidimensionally in patients with knee osteoarthritis (OA) using clinical, ultrasonographic and biochemical parameters, and in this respect, it was aimed to investigate the relation between OA and sarcopenia and to identify the most practical, easily accessible and inexpensive method for investigating sarcopenia.

Full description

102 patients with clinical and radiological diagnosis of knee osteoarthritis and 33 healthy control subjects were included in the study. A total of 135 subjects were evaluated using the European Working Group on Sarcopenia in Older People (EWGSOP) diagnostic criteria of sarcopenia. The first group consists of (OA) patients with sarcopenia, the second group consist of OA patients without sarcopenia and the third group is controls subjects. The detailed musculoskeletal system examination of the patients included in the study was carried out by a single physician, and complete blood count, renal function tests, electrolytes, total protein, albumin, 25 (OH) vitamin D, serum leptin, serum adiponectin, PTH, TSH and vitamin B12 values were recorded using the venous blood samples taken from the study group.Dual-X-ray absorptiometry (DEXA) is used to measure Body composition parameters and muscle mass measurements, isometric muscle strength evaluations, handgrip strength and gait speeds for diagnosis of sarcopenia. Short-form -36 (SF-36) The Nutritional Assessment-short form (MNA), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the International Physical Assessment Questionnaire Short Form (IPAQ-SF) and the Center for Epidemiologic Studies Depression Scale (CES-D scale) were administered to every patient as outcome measures.

Enrollment

135 patients

Sex

Female

Ages

50 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patients between the ages of 50-70
- Patients who have been followed up with the diagnosis of knee ostheoarthritis
- Patients who have been followed up with the diagnosis of knee ostheoarthritis and sarcopenia

Exclusion criteria

Previous history of any trauma/surgical history of the lower extremities (other than amputation)
Rheumatic diseases Contracture of the knee and the ankle of the intact limb
malignant disease
hyperthyroidism/ hypothyroidism
chronic inflammatory disease
diabetes mellitus, and uncontrollable heart and kidney diseases
pregnant women

Trial design

135 participants in 3 patient groups

sarcopenic patints with knee ostheoarthritis

Description:

12 patients between the ages of 50-70, who have been followed up with the diagnosis of knee Ostheoarthritis (OA) patients with sarcopenia.All subjects were evaluated by the European Working Group on Sarcopenia in Older People (EWGSOP) diagnostic criteria for the diagnosis of sarcopenia.

Treatment:

Diagnostic Test: Musculoskeletal ultrasound

Diagnostic Test: Dual-X-ray absorptiometry

Diagnostic Test: Isokinetic dynamometer

non sarcopenic patients with knee ostheoarthritis

Description:

90 patients between the ages of 50-70, who have been followed up with the diagnosis of knee Ostheoarthritis (OA) patients.

Treatment:

Diagnostic Test: Musculoskeletal ultrasound

Diagnostic Test: Dual-X-ray absorptiometry

Diagnostic Test: Isokinetic dynamometer

control group