The PRESS RA: Protein and Resistance Exercise Supplementation Study for Rheumatoid Arthritis (PRESSRA)

Johns Hopkins University

Status: Terminated

Conditions: Rheumatoid Arthritis

Treatments: Dietary Supplement: Protein; Other: Resistance Exercise Program; Dietary Supplement: Carbohydrate (Placebo)

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT02078375

R03AG045081 (U.S. NIH Grant/Contract)

NA_00088317

Details and patient eligibility

About

This study will evaluate if the combination of resistance exercise and protein supplementation will increase muscle strength and muscle mass among older individuals with rheumatoid arthritis (RA).

Full description

This study proposes a randomized trial to evaluate a tailored 16-week resistance exercise program, in combination with protein supplementation, for older individuals with RA. The exercise protocol in this study is distinctive because it combines dynamic and isometric (static) resistance exercise performed on specialized equipment that can accommodate the range of motion limitations frequently encountered in the older RA population. This study will also begin to evaluate if additional benefit can be achieved with daily protein supplementation

Enrollment: 23 patients

Sex: All

Ages: 60 to 95 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 60-95 years
• diagnosis of rheumatoid arthritis
• willing to participate in twice weekly exercise sessions

Exclusion criteria

• cognitive impairment
• recent heart surgery (within past 12 months)
• severe kidney disease
• use of supplemental oxygen
• presence of pacemaker
• diabetes that requires insulin for management
• allergy to soy or milk

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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23 participants in 2 patient groups, including a placebo group

Carbohydrate supplement

Placebo Comparator group

Description:

Participants will be enrolled in a twice weekly resistance exercise program. They will receive a carbohydrate supplement to take twice daily (once after exercise).

Treatment:

Other: Resistance Exercise Program

Dietary Supplement: Carbohydrate (Placebo)

Protein Supplementation

Experimental group

Description:

Participants will be enrolled in a twice weekly resistance exercise program. They will receive a twice daily protein supplement (once after exercise).

Treatment:

Other: Resistance Exercise Program

Dietary Supplement: Protein