The Prevalence and Clinical Characteristics of Children With Local Allergic Rhinitis

Mahidol University

Status

Completed

Conditions

Other Allergic Rhinitis

Treatments

Procedure: nasal allergen provocation test

Study type

Interventional

Funder types

Other

Identifiers

NCT02271620

759/25569(EC3)

Details and patient eligibility

About

To determine prevalence of local allergic rhinitis (LAR)
To evaluate clinical characteristic and severity of local allergic rhinitis
To measure changing of tryptase and Specific IgE for Dermatophagoides pteronyssinus (Dp) after nasal allergen provocation test (NAPT)

Full description

Children 8-18 years with NAR were recruited. A NAPT with Der p 1 solutions (NAPT-DP) at 200 AU/mL, 600 AU/mL and 2000 AU/mL at 15-minute interval was performed, respectively. The immediate responses to NAPT-DP were assessed using symptoms score, peak nasal inspiratory flow (PNIF) and acoustic rhinometry (ARM). The nasal tryptase and sIgE-DP were measured at baseline, 15 min and 1 h after positive NAPT-DP. Allergic rhinitis (AR) patients were used as positive control.

Enrollment

53 patients

Sex

All

Ages

8 to 18 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Children 8-15 years who were diagnosed with nonallergic rhinitis (NAR) at least 1 year
No respiratory infections in the previous 4 weeks
No following treatment of
systemic corticosteroid 4 weeks
intranasal corticosteroid 2 weeks
oral antihistamine 1 week
leukotriene antagonist 1 week

Exclusion criteria

Patients with underlying disease:
chronic rhinosinusitis and nasal polyp
immunological disease
chronic renal disease
hepatobiliary disease
cardiovascular disease
cancer
Parental withdraw consent
Patient with uncontrolled asthma, peak expiratory flow rate (PEFR) < 80% of predicted