The Prevalence of a Low Ankle-Brachial Index in Acute Cerebral Ischemia.

Jan Biziel University Hospital No 2 in Bydgoszcz

Status: Unknown

Conditions: Ischemic Stroke

Treatments: Device: ABI measurement; Device: Duplex scanning of carotid arteries

Study type: Observational

Funder types: Other

Identifiers

NCT03948399

JBUH-ABI-CIE-2018

Details and patient eligibility

About

Aim of the study is assessment the prevalence of the low ankle-brachial index (ABI) defined less than or equal 0.9 in patients with acute cerebral ischemic event (stroke or transient ischemic attack) and determinate the correlation between ABI and internal carotid artery stenosis (ICAS) in the acute cerebral ischemic patients.

The low ABI is a strong marker of generalized atherosclerosis. LEAD is a strong independent predictor for stroke.

Full description

Aim of the study is assessment the prevalence of the low ankle-brachial index (ABI) defined less than or equal 0.9 in patients with acute cerebral ischemic event (stroke or transient ischemic attack) and determinate the correlation between ABI and internal carotid artery stenosis (ICAS) in the acute cerebral ischemic patients.

The ABI is a non-invasive tool useful for the diagnosis of LEAD. The low ABI is a strong marker of generalized atherosclerosis. LEAD is a strong independent predictor for stroke. Significant ICAS is prevalent among patients having LEAD. Acute ischemic stroke due to significant ICAS has poor prognosis.

Patients with LEAD may be a suitable subgroup for screening for ICAS using duplex scanning.

Estimating the relationship between cerebral ischemic event and the ABI value could help better guide preventive and risk reduction strategies.

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Acute ischemic stroke or transient ischemic attack of anterior circulation
• Consent of patient

Exclusion criteria

• primary intracranial hemorrhage,
• venous sinus thrombosis,
• unconsciousness,
• intubation,
• inability to provide and write a consent application form.

Trial design

200 participants in 2 patient groups

STROKE GROUP

Description:

150 patients admitted to Stroke Unit with a diagnosis of acute ischemic stroke (IS) or transient ischemic attack (TIA)

Treatment:

Device: ABI measurement

Device: Duplex scanning of carotid arteries

CONTROL GROUP

Description:

50 individuals admitted to hospital without diagnosis of acute cerebrovascular disease; with diagnosis of dizziness, epilepsy, sclerosis multiplex.

Treatment:

Device: ABI measurement

Device: Duplex scanning of carotid arteries