The Prevalence of Local Immunoglobulin E (IgE) Elevation and Its Effect on Intranasal Capsaicin Therapy in the Non-allergic Rhinitis Population

The University of Texas System (UT)

Status and phase: Completed; Phase 3

Conditions: Non-allergic Rhinitis

Treatments: Drug: Intranasal capsaicin; Drug: topical lidocaine

Study type: Interventional

Funder types: Other

Identifiers

NCT05093478

HSC-MS-19-0333

Details and patient eligibility

About

The purpose of this study to determine the therapeutic response of non-allergic rhinitis patients that have been subtyped as non-allergic rhinitis with local IgE elevation or non-allergic rhinopathy to intranasal capsaicin based on visual analog scale and optical rhinometry, to determine the prevalence of non-allergic rhinitis with local IgE elevation in this study's cohort of patients with non-allergic rhinitis identified by rhinitis history and negative skin testing for allergic rhinitis, and to determine the change, if any, in intranasal IgE levels after capsaicin treatment.

Enrollment: 28 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic rhinitis

Exclusion criteria

• Active smoker
• Anatomic source of nasal symptoms
• Chronic rhinosinusitis or other nasal infection
• History of sinonasal malignancy
• Pregnancy or lactation
• Use of medication affecting nasal function (topical steroids, topical anticholinergics, oral antihistamines) in the previous 4 weeks
• Use or abuse of nasal decongestants.
• Positive skin prick test for allergic rhinitis

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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28 participants in 1 patient group

Treatment

Experimental group

Treatment:

Drug: topical lidocaine

Drug: Intranasal capsaicin