The Prevalence of Serum Thyroid Hormone Autoantibodies in Autoimmune Thyroid Diseases

Shandong First Medical University

Status: Unknown

Conditions: Autoimmune Thyroid Disease

Study type: Observational

Funder types: Other

Identifiers

NCT04075851

20190801

Details and patient eligibility

About

Thyroid hormone autoantibodies(THAA) in serum can Interfere radioimmunoassay for the determination of free thyroid hormones. Thyroid function test plays a key role in the diagnosis and treatment of autoimmune thyroid disease (AITD), and abnormal examination results in misdiagnosis and mistreatment. At present, the epidemiological results of THAA in AITD are inconsistent, and the pathogenesis has not been clarified. However, there is no relevant research on THAA in China. This project intends to collect AITD patients and healthy people, detecting THAA, at the same time testing thyroid function and thyroid autoantibodies, definiting positive rate of THAA in AITD patients, observing the effect of common therapeutic drugs for AITD on THAA, investigating the rule of THAA influencing thyroid function test results .This project will provide the basis and method for how to effectively avoid THAA interfering with thyroid function test.

Enrollment: 600 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• male or female with Hashimoto thyroiditis or Grave's disease aged for 18 to 65 years old

Exclusion criteria

• Had a thyroidectomy Had a thyroid fine needle puncture biopsy Autoimmune diseases Take drugs that affect the immune system

Trial design

600 participants in 4 patient groups

Hashimoto or Grave's disease patients in treatment

Description:

Draw 10 ml venous blood

Hashimoto or Grave's disease patients on initial treatment

Description:

10 ml of venous blood was extracted every month for three months

Pregnant woman with Hashimoto or Grave's disease

Description:

10 ml venous blood was extracted every month to postpartum for 6 months

Healthy crowd

Description:

Draw 10 ml venous blood