The PRIMO II Study: Paricalcitol Injection Benefits in Renal Failure Induced Cardiac Morbidity in Subjects With Chronic Kidney Disease (CKD) Stage 5

Abbott

Status and phase

Terminated

Phase 3

Conditions

Chronic Kidney Disease (CKD) Stage 5

Hypertrophy, Left Ventricular

Treatments

Drug: paricalcitol injection 4 mcg/mL

Drug: Placebo Injection 4 mcg/mL

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00616902

2007-005092-33 (EudraCT Number)

M10-221

Details and patient eligibility

About

To evaluate the effects of paricalcitol injection on cardiac structure and function over 48 weeks in subjects with Stage 5 Chronic Kidney Disease (CKD) receiving hemodialysis who have left ventricular hypertrophy (LVH).

Enrollment

12 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Stage 5 CKD receiving chronic hemodialysis three times per week for >= 3 months and <= 12 months from date of Randomization (Day 1).
Serum intact parathyroid hormone (iPTH) value between 100-350 pg/mL.
Serum calcium level between 8.4-10.5 mg/dL (2.1-2.6 mmol/L).
Phosphate < 7 mg/dL.
Serum albumin >= 3.0 g/dL (30 g/L).
Echocardiogram results:
- For females, left ventricular (LV) ejection fraction >= 50% and septal wall thickness between 11-17 mm.
- For males, LV ejection fraction >= 50% and septal wall thickness between 12-18 mm.
If the subject is receiving Renin Angiotensin-Aldosterone System (RAAS) inhibitors, the dose must have been stable for greater than one month prior to the Screening Period.
A technically adequate baseline cardiac magnetic resonance imaging (MRI).
If female, subject is not breast feeding or is not pregnant, or is not of childbearing potential, defined as postmenopausal for at least one year or surgically sterile, or is of childbearing potential and practicing one of the following methods of birth control:
Double-barrier method
Hormonal contraceptives for at least three months prior to and during study drug administration
Maintains a monogamous relationship with a vasectomized partner
Total abstinence from sexual intercourse during the study.

Exclusion criteria

Subject has previously been on active vitamin D therapy (calcitriol, paricalcitol, doxercalciferol, alfacalcidol) for a total duration greater than three months since the start of dialysis.
Subject has a history of an allergic reaction or significant sensitivity to paricalcitol or to drugs similar to the study drug.
Subject is expected to receive an increased dose of RAAS inhibitor (Angiotensin converting enzyme inhibitor [ACEi], Angiotensin II receptor blocker [ARB] or aldosterone inhibitor) during the course of the study.
Subject has clinically significant coronary artery disease (CAD) within 3 months prior to the Screening Period, defined as one of the following:
- Hospitalization for myocardial infarction (MI) or unstable angina; or
- New onset angina with positive functional study or coronary angiogram revealing stenosis; or
- Coronary revascularization procedure.
Subject has major cardiac valve abnormality linked with left ventricular hypertrophy (LVH) and/or diastolic dysfunction, defined as one of the following:
- Aortic valve area <= 1.5 cm2 or a mean gradient of > 20 mmHg; or
- Regurgitation lesions; more than moderate mitral regurgitation or more than moderate aortic regurgitation.
Subject has asymmetric septal hypertrophy.
Subject has had a severe cerebrovascular accident (CVA) within the last three months (e.g., hemorrhagic) prior to screening.
Full remission from a malignancy for less than one year except completely excised non-Melanoma skin cancer (e.g. basal or squamous carcinoma) or any history of bone metastasis.
Subject has co-morbid conditions.
Subject has received any investigational drug within 30 days prior to study drug administration or is currently enrolled in another clinical trial.
Subject has poorly controlled hypertension.
Subject has history of renal artery stenosis, primary aldosteronism or pheochromocytoma
Subject is taking calcitonin, bisphosphonates, cinacalcet, glucocorticoids (except topical or inhaled glucocorticoids)
Subject is currently receiving immunosuppressant therapy and/or high doses of glucocorticoids
Subject is known to be HIV positive.
Use of known inhibitors or inducers of cytochrome P450 3A (CYP3A) within two weeks prior to study drug administration
Subject is contraindicated for the MRI examination
Investigator considers subject unsuitable for any reason
Subject has a history of drug or alcohol abuse within six months prior to screening
Subject weighs more than 340 pounds (154 kg)
Subject has had a liver transplant