The Proactive Diagnostic Value of Hemostatic Biomarkers in Disseminated Intravascular Coagulation

Shandong University

Status: Enrolling

Conditions: Disseminated Intravascular Coagulation

Treatments: Other: no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT05995093

Hemostatic Biomarkers in DIC

Details and patient eligibility

About

The project was undertaking by Qilu Hospital of Shandong University, aiming to evaluate diagnostic performance of hemostatic biomarkers in disseminated intravascular coagulation.

Full description

Disseminated intravascular coagulation (DIC) is a life-threatening condition with high mortality, necessitating timely and accurate diagnosis for effective management. However, current diagnostic systems can not recognize DIC at its reversible phase, causing suboptimal treatment outcomes. Consequently, the current diagnostic criteria for DIC lacks earlier laboratory indicators. Therefore, the investigators aimed to assess the diagnostic potential of selected hemostatic biomarkers, including thrombin-antithrombin complex (TAT), soluble thrombomodulin (sTM), tissue plasminogen activator inhibitor complex (tPAI-C), α2-plasmin inhibitor plasmin complex (PIC) and anti-thrombin III (ATIII), in evaluating DIC, allowing for proactive diagnosis before the disease progresses into its irreversible phase.

Enrollment: 462 estimated patients

Sex: All

Ages: 18 to 94 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 years old, non-perinatal period, a hospitalization length of≥3 days.

Exclusion criteria

• primary hematologic diseases, decompensated liver cirrhosis, chemotherapy history.

Trial design

462 participants in 4 patient groups

non-DIC group

Treatment:

Other: no intervention

pre-DIC group

Treatment:

Other: no intervention

overt-DIC group

Treatment:

Other: no intervention

DIC group

Treatment:

Other: no intervention