The Prognostic and Predictive Value of the CA-125 Marker in Lung Cancer Monitoring

E-DA Hospital

Status: Unknown

Conditions: Lung Cancer

Treatments: Other: serum and pleural effusion CA-125 level

Study type: Observational

Funder types: Other

Identifiers

NCT02437760

EMRP49103N

Details and patient eligibility

About

The tumor associated CA-125antigen for diagnosis and follow-up of ovarian cancer was well defined. Increased serum CA125 level may have many diagnoses other than ovarian cancer, including breast, colorectal and lung cancer. 80% lung cancer patients were diagnosed at advanced stage. Malignant pleural effusion secondary to lung cancer represented the condition of cancer cell involved pleura.

The CA-125 level may reflect the extent of tumor involved in pleura (tumor burden), it could be correlated with the prognosis. This study was performed to examine the properties of CA-125 by measuring pleural and blood CA-125 levels in lung cancer with or without malignant pleural effusion; meanwhile to examine whether the rate of decline in CA 125 during primary therapy as a surrogate indicator for survival.

Enrollment: 200 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Histologically proved lung cancer

Exclusion criteria

• History of other cancers within the past 5 years
• Pregnancy or breast milk feeding
• TB pleuritis and peritonitis