The Prognostic Value of FDG PET/CT and Diffusion-weighed Imaging on Breast Cancer

Bagcilar Training and Research Hospital

Status: Completed

Conditions: Breast Neoplasms

Study type: Observational

Funder types: Other

Identifiers

NCT01942759

BC-PET-MR-01

Details and patient eligibility

About

The purpose of this study is to determine findings of positron emission tomography and diffusion weighted magnetic resonance in primary lesion and axillary metastasis of breast cancer and compare of two imaging modality in these patients.

Full description

We aimed that to correlate both primary lesion 18F-fluorodeoxyglucose (FDG) maximum standardized uptake value (SUVmax) and diffusion-weighted imaging (DWI) apparent diffusion coefficient (ADC) with clinicopathological prognostic factors and compare the prognostic value of these indexes in breast cancer in this study. The evaluated and compared parameters are SUVmax and ADC according to age, tumour size, lymph node metastasis, receptor status, histologic grade, modified Nottingham prognostic index.

Enrollment: 43 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Newly diagnosis of breast cancer for which surgical intervention is planned

Exclusion criteria

• patients received neoadjuvant chemotherapy
• before breast surgery

Trial design

43 participants in 6 patient groups

Histologic grade

Description:

According to the modified criteria of Bloom and Richardson grading system: grade 1, 2 and 3

Axillary metastasis

Description:

Group A: axillary lymph node metastasis Group B: no axillary lymphatic metastasis

Modified Nottingham prognostic index

Description:

NPI = pathological tumour size (cm) × 0.2 + lymph node stage (1, 2 or 3) + histological grade (1, 2 or 3) The cut-off points of the index were 3.4 and 5.4 to divide patients into the good (≤3.4), moderate (3.41-5.4) and poor (\>5.4) prognostic groups

Oestrogen receptor status

Description:

Negative Positive

Progesterone receptor status

Description:

Negative Positive

HER-2 neu status

Description:

Negative Positive