The Proposed Study Aims to Investigate the Efficacy of Quercetin as an Adjunctive to Mechanical Debridement in Treatment of Periodontitis

Mansoura University

Status and phase: Active, not recruiting; Phase 2

Conditions: Periodontal Pocket

Treatments: Drug: NSP and chitosan nanoparticles gel loaded by quercetin; Procedure: scaling and root planning; Drug: NSP and chitosan nanoparticles gel

Study type: Interventional

Funder types: Other

Identifiers

NCT06982248

A03030240H

Details and patient eligibility

About

the proposed study aims to investigate the effect of Quercetin in treatment of periodontitis patients

Full description

the proposed study aims to investigate the effect of Quercetin in treatment of periodontitis patients not having systemic diseases.the 2ry aim of study to estimate the neacular factor kabba B level in gingival crevicular fluids.

Enrollment: 60 estimated patients

Sex: All

Ages: 25 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients of both sexes with an age ranging between 25 and 55 years will be included in the study. Patients diagnosed as having periodontitis based on clinical and radiographic examinations will be included

Exclusion criteria

• Insulin dependent diabetes
• Thyroid disease
• Patients with sensitivity to the medication used in the study
• patients with a history of antibiotic use or anti-inflammatory drugs during the previous 3 months prior to the study will be excluded from the study.
• Additionally, patients with systemic diseases, smokers, pregnant and lactating patients, and patients not compliant with oral hygiene procedures will also be excluded

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

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60 participants in 4 patient groups

Group 1: Periodontitis patients treated by NSPT and chitosan nanoparticles gel loaded by quercetin

Experimental group

Description:

selected patients receive SRP and chitosan nanoparticles gel loaded by quercetin

Treatment:

Drug: NSP and chitosan nanoparticles gel loaded by quercetin

Group 2: Periodontitis patients treated by NSPT and chitosan nanoparticles gel.

Experimental group

Description:

selected patients receive SRP and chitosan nanoparticles gel

Treatment:

Drug: NSP and chitosan nanoparticles gel

Group 3: Periodontitis patients treated by NSPT only

Active Comparator group

Description:

NSPT

Treatment:

Procedure: scaling and root planning

Group 4: Periodontally healthy subjects.

No Intervention group

Description:

healthy individual act as control group