The Protein Disrupted in Schizophrenia 1 (DISC1) as a Novel Biomarker for Cardiac Disease

Norwegian University of Science and Technology

Status: Active, not recruiting

Conditions: Schizophrenia; Heart; Functional Disturbance; Heart Diseases

Treatments: Diagnostic Test: Cardiac Magnetic Resonance Imaging; Diagnostic Test: Echocardiography; Other: Blood sampling; Diagnostic Test: Electrocardiography

Study type: Observational

Funder types: Other

Identifiers

NCT06304233

606103

Details and patient eligibility

About

To study the association between DISC1 RNA expression levels and cardiac function in patients with schizophrenia.

Full description

Potential participants interested in the study will be screened for eligibility. Those who meet the eligibility criteria will be informed about the study, the expected investigations and its potential risks. All participants giving written informed consent will be enrolled into the study. Participants will be interviewed, given questionnaires, have blood and/or skin samples and clinical parameters taken. Cardiac function parameters will be measured using electrocardiography, echocardiography and magnetic resonance imaging.

Enrollment: 120 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with ICD-10 schizophrenia, schizotypal or delusional disorders (F20 to F29)
• Both inpatient and outpatient
• Capable of giving informed consent

Exclusion criteria

• Current or previous diagnosis of cancer
• Current or previous treatment with chemotherapy
• Current pregnancy
• Mothers less than 6 months post-partum

Trial design

120 participants in 2 patient groups

Diagnosed with Schizophrenia

Description:

Patients with a ICD-10 diagnosis of Schizophrenia will undergo investigations to assess cardiac function, cardiovascular disease risk factors and DISC1 mRNA expression. Participants eligible for MRI will be invited to undergo cardiac MRI in addition to echocardiography.

Treatment:

Diagnostic Test: Electrocardiography

Other: Blood sampling

Diagnostic Test: Echocardiography

Diagnostic Test: Cardiac Magnetic Resonance Imaging

No mental health diagnosis

Description:

Participants without a mental health diagnosis will be randomly selected from an existing population registered in the HUNT data and biobank for whom, echocardiographic data and biological samples are available.Those enrolled as controls will be invited to participate in the cardiac MRI portion of the study.

Treatment:

Diagnostic Test: Electrocardiography

Other: Blood sampling

Diagnostic Test: Echocardiography

Diagnostic Test: Cardiac Magnetic Resonance Imaging